Diabetic nephropathy is the most serious diabetes complications, diabetic
nephropathy is the main cause of death in patients with diabetes. Can take
preventive measures in advance in order to reduce mortality in patients
understand the causes of diabetic nephropathy, but also for the treatment of
some help. So, causes of diabetic nephropathy, what does?
1.Diabetic nephropathy the cause of a high blood sugar. Hyperglycemia is the
main cause of diabetic nephropathy, persistently high blood sugar can be the
formation of glomerular hyperperfusion, hyperfiltration, ball mesangial basement
membrane, capillary endothelial damage; further damage to the glomerular and
tubular; eventually lead to glomerular and glomerular atherosclerosis, resulting
in the destruction of nephron; caused by renal dysfunction.
(2) high-protein diet also contributed to the
main factors of diabetic nephropathy. Will increase the burden on the kidneys,
increased proteinuria, and a vicious circle. Therefore not more than 40 grams of
protein
3. Hypertension. Hypertensive renal
vascular resistance increased, reduction in renal blood flow, increased
intrarenal pressure, resulting in proteinuria, glomerulosclerosis and renal
failure. Diabetes and hypertension often coexist, it will form a vicious cycle,
patients with diabetes mellitus and hypertension are more prone to kidney
damage.
(4) high cholesterol. In patients with
diabetes, dyslipidemia is very common, which can promote glomerulosclerosis and
accelerate the progression of diabetic nephropathy.
(5) the increased blood viscosity and
microcirculatory disturbance is caused by one of the main factors of diabetic
nephropathy. Diabetes can occur microvascular disease and is often accompanied
by microcirculation, blood coagulation easy, thrombosis. Kidney microcirculation
thrombosis, renal units will ischemia and hypoxia, so that an increase in urine
protein, renal function decline.
