Synthesis rate of insulin in the body by which factors

Insulin and C-peptide in the same molecule secretion into the blood. Clinical patients treated with insulin, insulin antibodies present in serum, radioimmunoassay determination of blood insulin levels, by measuring plasma C-peptide levels in this case, to understand the endogenous insulin secretion. So, the synthesis rate of insulin in the body by which factors?
1, plasma glucose concentration is the most important factors affecting insulin secretion. After oral or intravenous glucose, insulin release was the two-phase reaction. Early rapid phase, the portal vein plasma insulin to achieve the highest value within two minutes, then rapidly decreased; delayed slow phase,
After 10 minutes, plasma insulin levels increased gradually, and lasted for more than one hour. The early fast phase of glucose to promote the storage of insulin release, delayed slow phase shows the synthesis of insulin and proinsulin change insulin.
2, containing more protein food after eating, blood amino acid concentrations increased, also increased insulin secretion. Arginine, lysine, leucine and phenylalanine are strong stimulation of insulin secretion.
Gastrointestinal hormone increased after meals, can stimulate insulin secretion such as gastrin, secretin, gastric Yitai, vasoactive intestinal peptide stimulate insulin secretion.