What is the pathogenesis of diabetic nephropathy?

Why do people with diabetes will lead to diabetic nephropathy? With diabetes to understand the mechanism of diabetic nephropathy, you can target to be effective in preventing diabetic nephropathy.
The pathogenesis of diabetic nephropathy are the following:
1, the glomerular atherosclerosis
Increased glomerular basement membrane collagen type Ⅳ messenger sugar, nucleic acid, the basement membrane, and ultimately the formation of diffuse mesangial nodular lesions, the occurrence of glomerular sclerosis.
2, high blood sugar of kidney damage
Poor glycemic control can accelerate diabetic nephropathy development, good blood glucose control can significantly delay the development. Hyperglycemia and advanced glycation end products generate increased cause mesangial cell proliferation, increased extracellular matrix, mesangial expansion, glomerular basement membrane thickening. Hyperglycemia, glomerular hyperperfusion, hyperfiltration state, across the capillary wall pressure increased, so that the expansion of mesangial cells, epithelial cell foot process fusion and produce dense droplets in glomerular epithelial cells detached from the basement membrane .
3, genetic factors
Diabetic nephropathy also showed family aggregation in some family history of hypertension in diabetic patients, the incidence of diabetic nephropathy was significantly higher than in patients without hypertension, family history.
What is the pathogenesis of diabetic nephropathy? In short, a variety of causes renal hemodynamic abnormalities caused by diabetic nephropathy. Must be comprehensive and integrated treatment of diabetic nephropathy, Chinese target Chinese medicine living pancreatic infiltration therapy can start from the root of the treatment of diabetic nephropathy, the results are satisfactory!